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Cholesterol sulfate is a critical, often overlooked mediator in this equation. When UVB light interacts with the skin, not only is vitamin D₃ synthesized, but cholesterol is also converted into cholesterol sulfate, a molecule that is both water-soluble and electrically active. This sulfated form facilitates the safe transport of cholesterol and vitamin D through the bloodstream without requiring carrier proteins, allowing them to act as coherent signaling molecules within the body’s structured w
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