Cluster headache pathophysiology. Pain afferents from the trigeminovascular system traverse the ophthalmic division of the trigeminal nerve, taking signals from the cranial vessels and dura mater …

Dec 22, 2025 · Cluster headache (CH), also known as histamine headache, is a primary neurovascular primary headache disorder, the pathophysiology and etiology of which are not well understood. As …

Mar 29, 2021 · Cluster headache is a debilitating primary headache disorder that affects approximately 0.1% of the population worldwide. Cluster headache attacks involve severe unilateral pain in the...

Cluster headaches cause excruciating, unilateral periorbital or temporal pain, with ipsilateral autonomic symptoms (ptosis, lacrimation, rhinorrhea, nasal congestion). Diagnosis is clinical. Acute treatment is …

Cluster headache is a neurological disorder characterized by episodes of severe headaches on one side of the head, typically around the eye and temple, lasting between 15 minutes to three hours. [1] …

Aug 12, 2025 · Common symptoms during a cluster headache include: Extreme sharp or stabbing pain, usually in, behind or around one eye. The pain can spread to other areas of the face, head and neck. …

During this period, new treatments have emerged, targeting known elements of cluster headache pathophysiology. This Review provides an updated perspective on the epidemiology, diagnosis, …

Nov 30, 2022 · Preclinical, neuroimaging and clinical studies have advanced our understanding of cluster headache pathophysiology. The trigeminovascular system, the trigeminal autonomic reflex, …

Dec 22, 2023 · Cluster headaches cause severe, one-sided head pain. These headaches usually last for at least 30 minutes and happen multiple times per day. They tend to follow a pattern, often showing …

Jul 4, 2023 · Cluster headaches are the most common of the primary headache type known as trigeminal autonomic cephalgias (TACs). They are relatively rare, plaguing 0.1% of the population, …