TMC207 inhibits the proton pump of mycobacterial ATP synthase, a critical enzyme in the synthesis of ATP for Mycobacterium tuberculosis. Resistance is achieved through mutations at position 63 or ...
That process, called carbon fixation, resulted in the assembly of two three-carbon molecules called 3-phosphoglycerate (3-PGA ...
Ancient microbes illustrate a particular kind of respiration in which carbon dioxide and hydrogen are combined to form acetic ...
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Enzymes, the core catalysts in life, drive critical biological processes ranging from metabolic regulation to energy ...
Determining enzyme mechanisms includes determining their kinetic and thermodynamic properties. Cyclic GMP-AMP synthase (cGAS), an intracellular sensor of dsDNA, is a central driver of inflammatory ...
Edited by Donald Ort, University of Illinois at Urbana Champaign, Urbana, IL; received December 10, 2024; accepted January 28, 2025 ...