Christian McCaffrey #23 of the San Francisco 49ers runs with the ball during the game against the Los Angeles Rams at Levi’s Stadium on November 9, 2025 in Santa Clara, California. Matthew Stafford #9 of the Los Angeles Rams throws during the game against the San Francisco 49ers at Levi’s Stadium on November 9, 2025 in Santa Clara, California.

Preview the Los Angeles Rams' NFL Week 10 matchup with the 49ers, including live stream, TV channel, odds, and game information.

NFL Week 10 odds, picks, predictions, TV channel, streaming information for the Sunday football game between Los Angeles Rams and San Francisco 49ers.

The Los Angeles Rams had a strong record entering Week 10, but they needed a dominant performance to even the season series against the San Francisco 49ers.

Los Angeles Rams cornerback Emmanuel Forbes scoops up a deflected pass from San Francisco 49ers quarterback Mac Jones for an interception.

San Francisco tight end George Kittle speaks to reporters after the 49ers' loss to the Los Angeles Rams on Sunday at Levi's Stadium.George Kittle believes 49ers' defense will improve after struggles i

WOODLAND HILLS, Ca. The Los Angeles Rams currently sit at 6-2 on the season, successfully avoiding a third straight slow start to their season. While they have leaped over one hurdle, they have another that remains in their path this week in the San Francisco 49ers.