Single-cell sequencing applications have accelerated breakthroughs in life sciences, leading to significant impacts for disease treatments. Single-nuclei RNA-sequencing (snRNA-Seq) has been shown to ...

Now, a team led by researchers at the Scripps Research Institute in La Jolla, California, and the University of California, San Diego (UCSD), has developed a high-throughput pipeline to analyze the ...

The team used two forms of single-nucleus RNA sequencing (snRNAseq ... Using snRNAseq avoids that dilemma by isolating the nuclei of each cell in a sample. Then, scientists can analyze the ...

This important study offers a molecular characterization of neurons and glia in the adult nervous system of the fruit fly Drosophila melanogaster. The study focuses on the progeny of a specific set of ...

Spatial transcriptomics is a cutting-edge technique that characterizes gene expression within sections of tissue, such as ...

Single-cell transcriptomics has revolutionized the study of cellular diversity and function by enabling gene expression ...

This difficulty has consequently made it more difficult to isolate intact nuclei or protoplasts, which are necessary for a thorough examination. Now, single-cell RNA (scRNA) sequencing has made ...

Using single-cell RNA sequencing, we mapped thousands of expression quantitative trait loci in yeast, including a variant in GPA1 that influences gene expression, cell-cycle occupancy, and mating ...

Study design, alignment, SNPs, indels, CNVs, structural variants, annotation, visualization, network analysis, variant interpretation and classification ...