The San Francisco 49ers have faced challenges with their defense due to injuries, leaving little room for error on offense.

Tom Brady, the former New England quarterback who earned his job and never gave it up after Drew Bledsoe was injured in 2001, ...

San Francisco 49ers head coach Kyle Shanahan doesn't have a return date for Brock Purdy, but he gave insight on what the team needs to see from him.

Brock Purdy is closing in on a return from injury for the 49ers, with an expected return by NFL Week 11. What about Mac Jones ...

San Francisco 49ers starting quarterback Brock Purdy won't be active again Sunday vs. the Los Angeles Rams according to a ...

Brock Purdy continues to be limited in practice by a lingering turf toe injury. Here's looking at why San Francisco has the ...

The Los Angeles Rams are changing kickers ahead of Sunday's game against the 49ers, who may have QB Brock Purdy active.

Quarterback Brock Purdy will miss his sixth straight start for the San Francisco 49ers due to a toe injury. He might be available in a backup role on Sunday against the Los Angeles Rams. Coach ...

Houston Texans quarterback C.J. Stroud will miss Week 10 after suffering a concussion last week against the Denver Broncos.

When the San Francisco 49ers lost another key defensive player for the season when rookie Mykel Williams went down with a knee injury, star tight end George Kittle said it was time for the offense to ...

Not making a deal the day of the NFL trading deadline created the illusion the 49ers were inactive when it come to adding to their roster.