A huge storm system crossing the U.S. threatens to unleash tornadoes Friday in the Mississippi Valley, blizzards in the northern Plains and dry, gusty conditions in Texas and Oklahoma that pose an extreme risk of wildfires.

Severe thunderstorms and the threat of tornadoes will persist across the Southeast through most of the weekend, while heavy rainfall and high winds associated with the storm are expected in parts of the mid-Atlantic and Northeast by Sunday.

The forecast comes days after an expansive storm similarly trekked across the U.S. last week, unloading snow in the northern Plains and bringing tornadoes and wildfires to the South. At least five storm-related deaths in Nebraska and Mississippi were tied to that storm.