Transfer RNA, more commonly referred to as tRNA, is well known for its key role in translating genetic material into protein. Recent discoveries about fragments of tRNA, which scientists had ...

Dutta’s study, “TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer,” was recently published in Nature ...

BIRMINGHAM, Ala. – Anindya Dutta, MBBS, Ph.D., and colleagues have described a novel form of gene regulation that is altered in bladder cancer, leading to the boosting of a gene pathway that helps the ...

A significant research paper published in the journal Cell Metabolism by the team of Prof. LIU Qiang at the University of Science and Technology of China (USTC) reveals the critical role of glutamate ...

BoNT/Aintoxication of LAN5 cells induces massive tRF changes. (A) Experimental design: 2×106 LAN5 cells/well were intoxicated by 10,000 MsLD50/mL BoNT/A, and small RNA-seq profiles from these cells ...

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...