The EMBO Journal

Chromatin modifier Hmga2 promotes adult hematopoietic stem cell function and blood regeneration in stress conditions

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The molecular mechanisms controlling the ...
The EMBO Journal

NBR1-mediated selective autophagy of ARF7 modulates root branching

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Auxin dictates root architecture via the Auxin ...
The EMBO Journal

ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis

Apoptosis and inflammation generally exert opposite effects on tumorigenesis: apoptosis serves as a barrier to tumour initiation, whereas inflammation promotes tumorigenesis. Although both events are ...
The EMBO Journal

High‐throughput sequencing for biology and medicine

Advances in genome sequencing have progressed at a rapid pace, with increased throughput accompanied by plunging costs. But these advances go far beyond faster and cheaper. High‐throughput sequencing ...
The EMBO Journal

Structural insights into mechanism and specificity of O‐GlcNAc transferase

Here, using X‐ray crystallography and structure‐guided mutagenesis, we provide the first molecular insights into the structure of OGT, how it binds UDP‐GlcNAc and aligns it for inverting O‐GlcNAc ...
The EMBO Journal

Single‐cell RNA sequencing of motoneurons identifies regulators of synaptic wiring in Drosophila embryos

This month's cover highlights the article Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation by A.-D. Brunner, M. Mann and colleagues. A new ultra-high ...
The EMBO Journal

The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation

Cover: Pseudostratified tracheal epithelium from newborn mice depicting cell boundaries (E‐cadherin, blue) and multiple motile cilia (acetylated α‐tubulin, red) protruding from multiple basal bodies ...
The EMBO Journal

The molecular chaperone Hsp90 delivers precursor proteins to the chloroplast import receptor Toc64

Precursor protein targeting toward organellar surfaces is assisted by different cytosolic chaperones. We demonstrate that the chloroplast protein translocon subunit Toc64 is the docking site for Hsp90 ...
The EMBO Journal

Implementing the LIM code: the structural basis for cell type‐specific assembly of LIM‐homeodomain complexes

The formation of cell type‐specific complexes is crucial for the development of complex organisms. Unique combinations of LIM‐homeodomain (LIM‐HD) proteins are thought to form a transcriptional ‘LIM ...
The EMBO Journal

TRPV1‐lineage neurons are required for thermal sensation

The ion‐channel TRPV1 is believed to be a major sensor of noxious heat, but surprisingly animals lacking TRPV1 still display marked responses to elevated temperature. In this study, we explored the ...
The EMBO Journal

Efficient use of a ‘dead‐end’ GA 5′ splice site in the human fibroblast growth factor receptor genes

We have investigated use of a conserved non‐canonical GA 5′ splice site present in vertebrate fibroblast growth factor receptor (FGFR) genes. Despite previous studies suggesting that GA at the ...