Toothaches can be sharp, throbbing, or constant—and finding fast relief is important. Over-the-counter pain relievers like ibuprofen, naproxen, or acetaminophen are often the first line of defense, ...

Painkillers Over-the-counter medication, such as acetaminophen and ibuprofen, can temporarily relieve toothache. However, a person needs to avoid giving aspirin to children under 16 years old.