Riboswitches are structured domains within the non-coding portions of some mRNAs, where they serve as metabolite-sensing genetic switches. Metabolite binding causes allosteric changes in the mRNA that ...

Riboswitches are RNA segments that switch genes on and off, either during DNA transcription or during protein translation, but little is known about the precise workings of this process. A new study ...

Figure 1: Binding of c-di-AMP by a ydaO motif RNA. Our further efforts to characterize this notable riboswitch candidate revealed that all of the members of this class examined respond selectively to ...

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The recently emerged field of bacterial riboswitches may be a good hunting ground for effective targets against bacterial infection, according to a report by Yale researchers in the journal Chemistry ...

In a recent study, researchers developed a low-cost RNA-based sensor that detects biomarker proteins. Researchers at Penn State University (PA, USA) have engineered an RNA-based sensor, a riboswitch, ...

In bacteria, many genes involved in the biosynthesis of cofactors such as thiamine pyrophosphate (TPP) are regulated by riboswitches, regions in the 5' end of mRNAs to which the cofactor binds, ...

RNA carries genetic information and performs diverse structural and catalytic roles in the cell. It can fold into defined three-dimensional shapes, allowing it to regulate gene expression, catalyze ...

Cell-free systems, which can express an easily detectable protein with a DNA or mRNA template without constraints of living cells, are attractive as foundations for biosensors. Moreover, by ...

A cell is a complex environment in which substances (metabolites) must maintain a correct state of equilibrium, which may vary depending on specific needs. Cells can maintain the proper concentrations ...

The role of RNA in information transfer and catalysis highlights its dual functionalities. Our laboratory has a long-standing interest in RNA folding, recognition, and catalysis. We are especially ...