The complexity and diversity of proteoglycan structure means that they have a range of functions that regulate cell behavior. Through multiple interactions of their core proteins and ...

Proteoglycans are ubiquitous molecules that function as critical components of the extracellular matrix. These proteins are composed of glycosaminoglycan chains that are covalently attached to a ...

Chondroitin sulfate proteoglycans (CSPGs), commonly obtained from salmon nasal cartilage, are a key ingredient of various health foods. As the popularity of health foods increases, scientists are ...

LA JOLLA, CA—Scientists at Scripps Research have developed a set of methods for the closer study of one of the least-accessible, least-understood players in biology: protein-sugar conjugates called ...

Proteoglycans—molecules consisting of a core protein with multiple sugar chains—are so complex that researchers usually study the protein and sugar components separately, which makes it difficult to ...

Basement membrane (BM) proteoglycans are more than charged filtering agents. These complex macromolecules can direct cell responses by a wide range of sophisticated mechanisms. BM proteoglycans are ...

Bone tissue is a complex structure, consisting of mineralized collagen fibers and a variety of non-collagenous proteins, including proteoglycans such as biglycan and decorin. These proteoglycans ...

Hepatitis B virus (HBV) infects more than 250 million people worldwide and can lead to chronic liver disease and liver cancer. Current antiviral therapies suppress viral replication but do not ...

Aggrecan, a major component of proteoglycan (PG) having chondroitin sulfate (CS) in cartilaginous tissues, has become increasingly popular as an ingredient in health food. In fact, proteoglycans from ...