How do we think, feel, remember, or move? It all depends on transmission of chemical signals in the brain, carried and released by molecular containers called vesicles. In a new study, researchers ...

Our model proposes that in synapses, ATM protein localizes predominately in presynaptic terminals, while ATR localizes on both side of synapse. ATM binds exclusively to VGLUT1+ vesicles, while ATR ...

Vesicle recycling in the presynaptic terminal at one end of a neuron, showing the role of dynamin during the last step of endocytosis (membrane retrieval), where the protein cuts off the vesicle from ...

Amyloid plaques accumulate years before dementia, driven by release of the Aβ peptide from amyloid precursor protein (APP) in neurons. Now, new evidence points to synaptic vesicles as acidic hotspots ...

Phosphorylation of α-synuclein at serine 129 has long been used as a marker of synucleinopathy—p-S129syn accumulates in Lewy bodies, after all. But does this modification have a physiological function ...

Researchers have used cryo-electron tomography to uncover new details of the molecular structure of synaptic vesicles, which help transport neurotransmitters in the brain. The study could inform ...