Nature

Resolving individual steps of Okazaki-fragment maturation at a millisecond timescale

DNA polymerase delta (Pol δ) is responsible for elongation and maturation of Okazaki fragments. Pol δ and the flap endonuclease FEN1, coordinated by the PCNA clamp, remove RNA primers and produce ...
Nature

Proteins at the Y-shaped DNA replication fork

Focusing on the schematic illustration in a, two DNA polymerase molecules are active at the fork at any one time. One moves continuously to produce the new daughter DNA molecule on the leading strand, ...
JSTOR Daily

Primer release is the rate-limiting event in lagging-strand synthesis mediated by the T7 replisome

Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 21 (May 24, 2016), pp. 5916-5921 (6 pages) DNA replication occurs semidiscontinuously due to the ...
The Scientist

Chromosome Ends in Double Jeopardy

As DNA strands ravel and unravel in an intricate dance, one notable event takes center stage: replication. This process is essential to life, but the finer details of its orchestrated steps are still ...
JSTOR Daily

Solution to the 50-year-old Okazaki-fragment problem

PNAS is the world's most-cited multidisciplinary scientific serial. It publishes high-impact research reports, commentaries, perspectives, reviews, colloquium papers, and actions of the Academy. In ...