Kickoff from Lucas Oil Stadium in Indianapolis is at 8 p.m. ET. The Buckeyes are 4-point favorites in the latest Ohio State vs. Indiana odds, while the over/under for total points scored is 46.5 via SportsLine consensus. Before making any Indiana vs. Ohio State picks, check out the college football predictions from the SportsLine Projection Model .

The Game is on. College football's best rivalry matchup is here to put an exclamation point on the 2025 regular season as No. 1 Ohio State hits the road against

Through 12 games the Ohio State defense has allowed just 93 points and for the first time in school history they have held 12 straight opponents to less than 17 points. The only team to record more than 300 yards against the Buckeyes this season was Texas in the season opener.

The Ohio State Buckeyes finally avoided stumbling against the rival Wolverines, helping to set up what might be Ryan Day's most successful campaign to date. That's a loft ambition, of course, considering the Buckeyes just won the College Football Playoff (CFP) a year ago.

It's the game of the year in college football when it's 1 vs 2 for the Big Ten Championship. Here's the CFN Big Ten Championship preview, prediction, and betting line.

Check out the complete details on how to watch the 2025 Big Ten Football Championship game including date, time and TV channel.

Ohio State’s regular season was as close to flawless as one could script. It’s a resume that needs no introduction, but Indiana is looking at the No. 1 team in SP+, a plus-29.3 scoring margin, a top-five rank in both offensive and defensive EPA per play and a surgical 69 percent conversion rate in the red zone.