Mechanistic model for MTOC maturation in GV oocytes. The MTOC (grey) activates near the oocyte cortex, which requires recruitment of CKAP5 and TACC3. After activation, MTOC migrates to the nuclear ...

Communication between oocytes and granulosa cells is essential for oocyte formation, dormancy, reawakening, and maturation. Researchers have demonstrated that a protein complex called the exocyst ...

Researchers have found that a carefully orchestrated act of X-chromosome 'yoyo' predicts the successful and efficient development of mammalian egg cells. The findings could pave the way for generating ...

The new method offers researchers a powerful new platform to investigate the molecular mechanisms that control oogenesis, the process by which egg cells develop, and lays important groundwork for ...

Lower ovarian reserve was associated with accelerated pace of aging and higher risk scores for metabolic disease. Learn more ...

A new review suggests CoQ10 could rejuvenate aging oocytes and enhance embryo quality, offering hope for women facing age-related fertility challenges while spotlighting the need for rigorous clinical ...

Nutritional status regulates energetically costly functions like reproduction. 1 Fat tissue serves as both an energy reserve and a metabolic sensor. This sensor operates through a series of ...

A large genome-wide association study meta-analysis analyzed data on 42 female reproductive health diagnoses from the Estonian Biobank and FinnGen. Researchers looked at data from around 300,000 women ...

The development of artificial grafts that may recapitulate the tissue microarchitecture is one of the most ambitious and complex approaches to understanding molecular mechanisms in an in vitro ...