A single arm phase Ib study of RAD001 and sunitinib in patients with advanced renal cell carcinoma (RCC). Long-term versus short-term androgen deprivation combined with high-dose radiotherapy for ...
F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche, Inc. have described fluorescent probes acting as monoglyceride lipase (MGLL; MAGL) inhibitors reported to be useful for diagnostic imaging of MAGL.
In mice, a novel monoacylglycerol lipase inhibitor (MCH11) reduced ethanol intake and drinking motivation, yielding anxiolytic and antidepressant-like effects, with sex-dependent efficacy. A new ...
Two classes of weight-loss agents are currently available by prescription: noradrenergic agents for short-term weight loss and a lipase inhibitor for long-term weight loss. Adverse effects include ...
Monoacylglycerol lipase (MAGL), a member of the serine hydrolase family expressed in the brain and peripheral tissue, is a key enzyme in the hydrolysis of monoglycerides, converting 2-arachidonoyl ...
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