Missing DNA replication step revealed in first image of pre-initiation complex

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...
Nature

Reconstituting transcription–translation-coupled DNA replication within complex in vitro biological systems

Reconstructing transcription–translation-coupled DNA replication (TTcDR) in artificial systems is crucial for creating synthetic life; however, existing approaches face limitations mainly due to their ...
Phys.org

DNA replication in early embryos differs from previous assumptions, study shows

A new discovery by researchers at the RIKEN Center for Biosystems Dynamics (BDR) in Japan upends decades of assumptions regarding DNA replication. Led by Ichiro Hiratani and colleagues, the ...
Nature

Machine learning-based prediction of DNA G-quadruplex folding topology with G4ShapePredictor

Deoxyribonucleic acid (DNA) is able to form non-canonical four-stranded helical structures with diverse folding patterns known as G-quadruplexes (G4s). G4 topologies are classified based on their ...