A risky but often lifesaving surgery that removes damaged parts of the small intestine can leave patients facing a new threat: serious liver damage with no available treatment. Now, scientists have ...

During drug development, researchers need to perform adequate nonclinical testing to ensure a drug’s safety and efficacy before starting clinical trials. An important aspect they must evaluate is a ...

Researchers have developed a human intestinal cell model that closely mimics the structure and function of the human gut, enabling more precise prediction of drug-induced gastrointestinal toxicity ...

Before orally administered drugs can make their way throughout the body, they must first bind to membrane proteins called drug transporters, which carry compounds across the intestinal tract and help ...

Though studies evaluating the effects of posture on the absorption of drugs have been conducted, a systematized review revealed critical gaps in methodology. Of 18 original research articles selected ...

New research shows that certain flavonols from everyday foods can shut down the body’s drug-resistance machinery, potentially paving the way for more effective treatments, but clinical hurdles remain.

Drugs that are taken orally need to pass through the lining of the gastrointestinal (GI) to be taken up. Transporter proteins found on cells that line the GI tract help with this process, but for many ...

The way in which the body processes cholesterol affects the risk of cardiovascular diseases. LDL cholesterol is obtained from saturated fats in food and from hepatic cholesterol synthesis. Its ...

Rahul Dhanda is at the helm of a new therapeutics company, Syntis Bio, which launched this week. But for Dhanda, the company got its start 20 years ago, when he sent a cold email to Bob Langer, PhD, ...