Researchers discovered that a small region of the PRC2 protein complex acts as a functional switch controlling gene silencing. Removing this domain stopped cancer cell growth, highlighting a potential ...

The coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is a highly virulent virus. Evidence suggests that disruption of host ...

Histone modification is an epigenetic mechanism that regulates gene expression by altering chromatin structure and DNA accessibility for transcription. Histone modification is regulated by various ...

Strands of DNA wrapped around a histone. Credit: Molekuul/Science Source Histones are among the most abundant proteins in the body. They act as spools that help compact DNA so our enormous genomes ...

Our group has contributed to the molecular and functional understanding of histone mark and DNA methylation mark readout by writer, reader and eraser proteins, as well as investigated the crosstalk ...

Researchers have completed a comprehensive analysis of cancer-associated histone mutations in the human genome, featuring both biochemical and cellular characterizations of these substrates. Their ...

EpiciphAI公司正研发一款液体活检产品，通过检测无细胞染色质上的组蛋白标记，确定染色质片段的组织来源，并区分该组织中与疾病相关的状态。目前该公司仍处于种子前阶段，其技术的首个应用场景为难以进行活检的组织的癌症诊断与病情监测。

Cardiovascular disease remains the leading cause of mortality worldwide, necessitating deeper insights into its molecular underpinnings beyond genetic predisposition. Epigenetic modifications, ...

Post-traumatic osteoarthritis develops rapidly after joint injury, yet current treatments largely address symptoms rather ...