Getting therapeutic drugs past the blood-brain barrier has long been a major challenge in treating brain diseases. Now, researchers have explored how cholesterol-modified heteroduplex oligonucleotides ...

Scientists have successfully used CRISPR gene-editing technology to eliminate 50% of head and neck tumors in model animals, marking a potential revolution in cancer treatment, Israeli researchers ...

Gene editing in plants remains challenging, with the traditional non-homologous end-joining (cNHEJ) repair pathway often hindering precision. In this study, researchers advanced CRISPR-Cas-based gene ...

Patent Publication (WO 2025 168944 A1) and subsequent PCT filing solidifies R&D leadership in Advanced Neurotherapeutics for Alzheimer's, Parkinson's and Related Disorders CHARLOTTESVILLE, Va., Sept.

This study revealed that, by binding to lipoproteins, cholesterol-conjugated heteroduplex oligonucleotides (Chol-HDOs) can remain in the bloodstream for longer and reach brain tissue much more ...