News Medical

Study identifies potential gain of function mutation in retinoblastoma

A new research paper was published in Volume 16 of Genes & Cancer on January 20, 2025, entitled, "Analysis of pathogenic variants in retinoblastoma reveals a potential gain of function mutation." ...
EurekAlert!

Research Spotlight: Surprising gene mutation in brain’s immune cells linked to increased Alzheimer’s risk

Dominika Pilat, PhD, and Ana Griciuc, PhD, of the Department of Neurology at Massachusetts General Hospital are the lead and senior authors of a paper published in Neuron, “The Gain-of-Function ...
Nature

The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function

The Nature Index 2025 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...
Nature

Chronic Mucocutaneous Candidiasis and STAT1 Gain-of-Function Mutations

Chronic mucocutaneous candidiasis (CMC) is a condition characterised by recurrent or persistent infections of the skin, nails and mucous membranes caused predominantly by Candida species. A ...
News Medical

Study reveals how a microglial mutation increases risk for Alzheimer's disease

Dominika Pilat, PhD, and Ana Griciuc, PhD, of the Department of Neurology at Massachusetts General Hospital are the lead and senior authors of a paper published in Neuron, "The Gain-of-Function ...
ascopubs.org

Association of co-occurring KRAS and gain of function TP53 mutations with aggressive metastasis through comprehensive genomic profiling of pancreatic ductal adenocarcinoma.

Epidemiology and outcomes of disseminated intravascular coagulation in pancreatic cancer patients admitted with sepsis: Insights from a national database. This is an ASCO Meeting Abstract from the ...
Houston Chronicle

Gain-of-function research is more than just tweaking risky viruses – it’s a routine and essential tool in all biology research

The term “gain of function” is often taken to refer to research with viruses that puts society at risk of an infectious disease outbreak for questionable gain. Some research on emerging viruses can ...