The serine proteinase plasmin is the key fibrinolytic enzyme that dissolves blood clots and also promotes cell migration and tissue remodeling. Here, we report the 2.65 Å crystal structure of a ...

image: Enzyme substrate specificity involving material conversion processes is pertinent to e.g. biochemistry, metabolic engineering, and environmental remediation; however, it is one of the most ...

Oxidoreductases are key enzymes in biocatalysis, but their dependence on the cofactor nicotinamide adenine dinucleotide (phosphate) (NAD(P)) presents challenges due to its high consumption and ...

Many enzymes require cofactors such as nicotinamide adenosine dinucleotide (NAD +) or nicotinamide adenosine dinucleotide phosphate (NADP +) to shuttle electrons between reactions. Artificial redox ...

Researchers have captured real-time "molecular movies" showing how an enzyme changes shape during catalysis. The study was published in Nature Communications. Using an advanced technique called ...

Researchers have identified a molecule sent by fat cells to the fly brain that senses when they have had enough food and inhibits feeding. Researchers have identified a molecule sent by fat cells to ...

Cells use flavin monooxygenases to break down foreign molecules by adding oxygen atoms to them. Biochemists have long assumed that the enzymes use a particular cofactor adduct to add the oxygen. A new ...

The research, published in The FEBS Journal, improves understanding of classical homocystinuria, a hereditary metabolic disorder, and proposes new potential therapeutic approaches. This genetically ...

Biochemical assays are a common approach used to identify inhibitors of epigenetic-modifying enzymes. Challenges that arise when designing these assays are centered on choosing histone substrates that ...

Enzymology is the study of enzymes and enzyme-catalyzed reactions. Enzymes are biological catalysts that accelerate the rate of biological reactions. They can also perform multiple reactions ...