The shikimate pathway is fundamental for the biosynthesis of aromatic amino acids—tryptophan, tyrosine and phenylalanine—in plants, bacteria and fungi. This pathway, which is absent in mammals, has ...

One of the key features in the evolution of more complex organisms is the emergence of allosteric regulation. Allostery is a process by which a protein’s activity can be modulated by binding an ...

Most proteins comprise two or more domains from a limited suite of protein families. These domains are often rearranged in various combinations through gene fusion events to evolve new protein ...

The first full-length structures of the human angiotensin-converting enzyme (ACE) have been determined by researchers from the University of Cape Town (UCT) using cryo-electron microscopy (cryo-EM).

Antimicrobial resistance (AMR) is a global health problem. Handful species of drug-resistant pathogens, including Neisseria gonorrhoeae, could become untreatable due to a high degree of AMR. A team of ...

Researchers at the Centre for Genomic Regulation have developed a new technique for identifying allosteric sites in proteins (Nature 2022, DOI: 10.1038/s41586-022-04586-4). While many drugs target the ...

Johns Hopkins Medicine scientists report that they have probed the atomic structure of proteins to add evidence to the notion that the wobbles, shakes and quivers of proteins play a critical role in ...