Most of the genetic risk for developing a substance use disorder comes from genes that broadly affect how our brains process rewards, regulate impulses and weigh consequences—not from genes that ...

New research suggests the weight-loss medications could be powerful tools in tackling substance use disorders.

Researchers analyze 2.2 million genomes to show that addiction risk is primarily driven by broad genes affecting brain wiring and impulse control, not drug-specific traits.

Relapsing after quitting cocaine is not simply a matter of willpower — it reflects physical changes in the brain, according to new research. Scientists have found that repeated cocaine use reshapes ...

Drug addiction carries an extremely high risk of relapse, as cravings can be reignited by minor stimuli even long after one has stopped using. Previously, this phenomenon was attributed to a decline ...

A popular class of drugs for treating diabetes and obesity may reduce addiction, including abuse of alcohol, tobacco, cannabis, opioids and cocaine, according to research published March 4 by ...

Researchers identify PV neurons in the prefrontal cortex as the gatekeepers of drug addiction relapse, offering a new target for precision treatment.

Health Affairs' Rob Lott interviews Nora Volkow, director of the National Institute on Drug Abuse (NIDA) at the National Institutes of Health, to discuss addiction as a brain disorder, treatments for ...

An international research team led by the Universitat Jaume I (UJI) has shown that the cerebellum, contrary to what was thought, fulfils functions that go beyond the motor sphere and can be ...

NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of ...