Picture in your mind a traditional “landline” telephone with a coiled cord connecting the handset to the phone. The coiled telephone cord and the DNA double helix that stores the genetic material in ...
Picture in your mind a traditional "landline" telephone with a coiled cord connecting the handset to the phone. The coiled telephone cord and the DNA double helix that stores the genetic material in ...
DNA gyrase, a bacterial type II topoisomerase, is instrumental in maintaining DNA supercoiling during replication and transcription. Owing to its absence in higher eukaryotes, it represents an ...
A protein isolated from Escherichia coli complements the DNA gyrase A (NalA) protein to generate an activity that relaxes supercoiled DNA. Oxolinic acid, a known inhibitor of DNA gyrase, blocks this ...
Scientists uncover new mechanism in bacterial DNA enzyme opening pathways for antibiotic development
Researchers from Durham University, Jagiellonian University (Poland) and the John Innes Centre have achieved a breakthrough in understanding DNA gyrase, a vital bacterial enzyme and key antibiotic ...
Researchers from Durham University, Jagiellonian University (Poland) and the John Innes Centre have achieved a breakthrough in understanding DNA gyrase, a vital bacterial enzyme and key antibiotic ...
This is a preview. Log in through your library . Abstract DNA gyrase is the bacterial DNA topoisomerase (topo) that supercoils DNA by using the free energy of ATP hydrolysis. The enzyme, an A2 B2 ...
Scientists reveal how a 'molecular machine' in bacterial cells prevents fatal DNA twisting, which could be crucial in the development of new antibiotic treatments. DNA replication is vital to all ...
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