One of the most expensive steps in manufacturing protein drugs such as antibodies or insulin is the purification step: isolating the protein from the bioreactor used to produce it. This step can ...

The new cell-free protein crystallization (CFPC) method includes direct protein crystallization and is a major headway in the field of structural biology. This technique will enable the analysis of ...

The new cell-free protein crystallization (CFPC) method developed by Tokyo Tech includes direct protein crystallization and is a major headway in the field of structural biology. This technique will ...

Correlative cryo-light microscopy and cryo-FIB workflows improve the localization and preparation of intracellular crystals ...

Crystallization produces active pharmaceutical ingredients (APIs) in a desired solid form, while conferring specific properties such as particle size, shape and purity. The latter is typically the ...

Most researchers know they need a pure protein. Few talk about how genuinely difficult it is to get one. A cell lysate contains thousands of proteins competing for the same space. Your target is in ...

In the downstream portion of any bioprocess, one must pick through the dross before one can seize the gold—the biotherapeutic that the bioprocess was always meant to generate. Unfortunately, the dross ...

Engineers devised a way to purify protein drugs during manufacturing. Their approach, which uses nanoparticles to rapidly crystallize proteins, could help make protein drugs more affordable and ...