Aconsortium of 17 laboratories worldwide has presented results contradicting a highly cited study that described a technique to create conditional knockout mice using CRISPR. The preprint, published ...
We describe a system for introducing guide RNAs (gRNAs) to Cas9-expressing hematopoietic stem cells, which are used to generate mice with gene knockouts in the immune system. By using different ...
Species: Mouse Genes: Gba1 Modification: Gba1: Conditional Knock-out Disease Relevance: Parkinson's Disease Strain Name: B6.129-Gba1 tm1Clk /J Genetic Background: Backcrossed 11 generations to ...
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