Watch the best plays from San Francisco 49ers RB Christian McCaffrey's 141-yard game against the Jacksonville Jaguars in Week 4 of the 2025 NFL season.

The San Francisco 49ers suffered another major injury and didn’t have enough to overcome those issues in a Week 6 loss to the Tampa Bay Buccaneers.

Los Angeles Rams linebacker Nate Landman tackles San Francisco 49ers running back Christian McCaffery to force a fourth down.

Sunday’s Week 2 matchup between the 49ers and Saints was more entertaining than it had any right to be, and the Niners have a 2-0 record that shows that guts matter a heck of a lot in the NFL. Here are the studs and duds (in no particular order) from the Niners’ 26-21 win.

Instagram/Olivia Culpo Christian McCaffrey, Colette McCaffrey, and Olivia Culpo. Earlier today, Culpo shared additional highlights from the game, posting a carousel of photos featuring Colette and Christian. The former pageant queen showed her team spirit ...

The lowly Titans allow 146.8 rushing yards per game, the third-worst mark in the NFL. That's music to Jeanty's ears. Brock Bowers looks unlikely to play, which means Jeanty could have an even bigger role in the offense. Look for the rookie back to carve up Tennessee and put six points on the board.

San Francisco 49ers running back Christian McCaffrey spins past multiple Tampa Bay Buccaneers defenders for a 23-yard gain.