Asbestos exposure has long been considered the primary cause of mesothelioma, influencing the course of thousands of lawsuits. However, an ever-increasing body of literature supports the thesis that ...

Patients with BAP1-mutated renal cell carcinoma who were treated with Lynparza obtained responses with favorable side effect profiles. Patients with renal cell carcinoma (RCC) whose tumors had gene ...

A new study reveals that tumors lacking a protein called BAP1 have an ineffective immune reaction against cancer, thus rendering immunotherapies ineffectual, particularly in uveal melanomas (UM). The ...

Comparative analysis of the chromosomal origins of circulating nucleic acids in breast and prostate cancer. Background: CDKN2A and NF2 are inactivated in most MPM, but no other recurrent mutations are ...

New study from researchers in Finland and the United Kingdom reveals that tumors lacking a protein called BAP1 have an ineffective immune reaction against cancer, thus rendering immunotherapies ...

The BAP1 gene is mutated in up to 20% of liver cancer patients, but just how the abnormality promotes the growth of liver tumors is a big unknown. Researchers at Hubrecht Institute and Radboud ...

Perioperative chemotherapy with gemcitabine plus cisplatin followed by radical liver resection versus immediate radical liver resection alone in gallbladder carcinoma or in front of radical resection ...

Researchers have identified covalently closed circular RNAs (circRNAs) from key genes involved in leukemia development and provided greater understanding of their roles in haematological malignancies.

Immunotherapies using immune checkpoint inhibitors (ICI) have dramatically improved cancer survival in the last decade, resulting in the Nobel Prize for Medicine in 2018. Unfortunately, a significant ...