San Francisco 49ers running back Christian McCaffrey (23) stiff-arms New York Giants cornerback Andru Phillips (22) during the third quarter of an NFL football game, Sunday, Nov. 2, 2025, in East Rutherford, N.J. Credit: AP/Frank Franklin II

Can the 49ers' defense overcome injuries and a surging Rams offense? Keys to securing another victory and sweeping their division rival.

Sunday, in the media room at MetLife Stadium, where the New York Jets, the New York Giants and NFL players’ ACLs go to die each week, San Francisco 49ers head coach Kyle Shanahan subtly gave the most revealing update on quarterback Brock Purdy’s lingering toe injury.

The Rams and 49ers rewrite a new chapter into their famed rivalry on Sunday. Here's where the Rams have the edge.

The San Francisco 49ers got back to winning ways on Sunday, and it was thanks in large part to another strong performance from star running back Christian McCaffrey. The Niners were on the road at MetLife Stadium for Week 9. They took down the New York Giants, 34-24, to improve to 6-3 on the season.

The 49ers have yet to open the practice window for Brandon Aiyuk to return, which should start to set in a harsh reality.

San Francisco 49ers QB Mac Jones got effective protection to beat the Giants, but credit some of that success to Kyle Shanahan's plan for how to keep New York's vaunted pass rush from being a factor.

Kyle Shanahan provides updates on 49ers quarterback Brock Purdy, injured stars entering Week 10 game originally appeared on NBC Sports Bay Area SANTA CLARA — Quarterback Brock Purdy appears to be getting closer to a return.