WOODLAND HILLS, Ca. Whenever the Los Angeles Rams and the San Francisco 49ers get together, it's always a physical battle that gets determined in the trenches. For one Rams linebacker, it was his platform for a career day.

Expert recap and game analysis of the Los Angeles Rams vs. San Francisco 49ers NFL game from November 9, 2025 on ESPN.

The Los Angeles Rams defeated the San Francisco 49ers 42-26 on Sunday, and tight end Tyler Higbee was mic'd up for the affair.

The Rams' quarterback had a stellar performance on Sunday, throwing for 280 yards and four touchdowns in their 42-26 win over the 49ers. His second touchdown pass of the day gave him 400 passing touchdowns in his career, making Stafford just the ninth quarterback in NFL history to reach that threshold.

The NFC West is loaded at the top, and two of the division's contenders meet on Sunday when the 6-3 San Francisco 49ers host the 6-2 Los Angeles Rams. This is the second meeting between these two rivals, as the 49ers won the Week 5 matchup 26-23 in overtime on Thursday Night Football.

The San Francisco 49ers fell to the Los Angeles Rams on Sunday. Here's who had the best and worst days, according to Pro Football Focus.

Oct 12, 2025; Baltimore, Maryland, USA; Los Angeles Rams quarterback Matthew Stafford (9) speaks with head coach Sean McVay during the second half of the game against the Baltimore Ravens at M&T Bank Stadium. Mandatory Credit: Peter Casey-Imagn Images / Peter Casey-Imagn Images

The way Matthew Stafford and the Los Angeles Rams picked apart the injury-riddled defense for San Francisco, it raised questions about why the 49ers weren’t more aggressive before last week’s trade deadline.