The San Francisco 49ers couldn’t have been much worse in a Week 10 loss to the Los Angeles Rams. Here are the highlights.

Matthew Stafford extended his MVP campaign with 280 yards and four more touchdowns, pushing the Rams to 7-2. Los Angeles' fierce defense also forced

The San Francisco 49ers had a rough outing in Week 10, falling to the Los Angeles Rams 42-26. That put San Francisco at a 6-4 record, dropping them to third place in the NFC West, and outside of the playoff picture as a whole.

These two teams are separated by just a half game in the middle of the NFC West standings. While the first-place Seattle Seahawks are taking on the last-place Arizona Cardinals, the other two NFC West teams will be facing off on Sunday,

The Week 10 loss to the Los Angeles Rams was by far the worst of the season for the San Francisco 49ers. It wasn't just because it was to a divisional opponent,

The Rams' quarterback had a stellar performance on Sunday, throwing for 280 yards and four touchdowns in their 42-26 win over the 49ers. His second touchdown pass of the day gave him 400 passing touchdowns in his career, making Stafford just the ninth quarterback in NFL history to reach that threshold.

Christian McCaffrey #23 of the San Francisco 49ers runs with the ball during the game against the Los Angeles Rams at Levi’s Stadium on November 9, 2025 in Santa Clara, California. Matthew Stafford #9 of the Los Angeles Rams throws during the game against the San Francisco 49ers at Levi’s Stadium on November 9, 2025 in Santa Clara, California.

The way Matthew Stafford and the Los Angeles Rams picked apart the injury-riddled defense for San Francisco, it raised questions about why the 49ers weren’t more aggressive before last week’s trade deadline.

The Los Angeles Rams had a strong record entering Week 10, but they needed a dominant performance to even the season series against the San Francisco 49ers.

NFL Week 10 odds, picks, predictions, TV channel, streaming information for the Sunday football game between Los Angeles Rams and San Francisco 49ers.

Los Angeles Rams cornerback Emmanuel Forbes scoops up a deflected pass from San Francisco 49ers quarterback Mac Jones for an interception.