As a junior, Jackson won the Jim Thorpe Award, given to the nation's best defensive back. The Titans selected him 18th overall the next spring. Jackson and Eagles wide receiver A.J. Brown were teammates in Tennessee for two seasons before Jackson left to sign with the Giants after the 2020 season.

In the wake of Darius Slay‘s release from the Philadelphia Eagles, many questioned what the team would do at the position. The franchise did not add any notable names in free agency at the corner position.